People
Pascal Amireault
Researcher, Spleen and transfusion group
INSERM
pascal.amireault@inserm.fr
Pierre Buffet
Professor, Spleen function in physiology and disease group
Université de Paris
pierre.buffet@inserm.fr
Lucie Dumas
PhD student, Spleen function in physiology and disease group
Université de Paris
lucie.dumas@inserm.fr
Aurélie Fricot
Engineer, Spleen function in physiology and disease group
INSERM
aurelie.fricot@inserm.fr
Papa Alioune Ndour
Associate Professor, Red cell clearance in Malaria group
Université de Paris
alioune.ndour@inserm.fr
Camille Roussel
, Spleen function in physiology and disease group
Université de Paris-APHP
camille.roussel@inserm.fr
Abdoulaye Sissoko
Post-Doc, Spleen function in physiology and disease group
U1134 / Institut Pasteur
abdoulaye.sissoko@inserm.fr
Mickael Marin
Engineer, Spleen and transfusion group
mickael.marin@inserm.fr
Alumni
Ben Othmene Yosra
Duverdier Clémence
Ben-Moumen Souheila
Cacan Zeynep
Leblanc Louise
Cissé Astan
Lavergne Alexis
Gauthier Raphaël
Perillaud Claire
Larreche Sebastien
Guery Romain
Tantaoui Ilhame
Taieb Aida
Siriez Jean-Yves
Chartrel Nathalie
Gay Frederick
Mouri Oussama
Ciceron Liliane
Danis Martin
Biligui Sylvestre
Diakite Seidina
Thellier Marc
Jaureguiberry Stephane
Duez Julien
Safeukui Innocent
Volle Geoffroy
Dépond Mallorie
Henry Benoît
Hadjou Youcef
Carret Valentine
Benletif Mounir
Diallo Aissatou Bailo
Chambrion Charlotte
Angella Lucia
Carucci Mario
In 2009, Mario got a master degree in biotechnology for human health from the Università di Siena in Italy. He studied the role of scaffold molecule KSR in cytotoxic activity of natural killer cells.
In 2015, he got a PhD in molecular pathogenesis, immunology and control of transmissible agents from the Università di Perugia, in Italy. He worked on the inhibition of Plasmespin V, an essential enzyme for protein export of P.falciparum parasites, a key factor in parasite’s virulence. He developed an innovative autologous expression system for large-scale production of P.falciparum proteins in the parasite itself, using the protein export system mediated by the Plasmepsin V.
After the PhD, he had a short six-months experience in applied research being responsible of a project called “Cow are you?” supported by Regione Umbria, in Italy. This project was focused on the design and production of a diagnostic kit based on lateral flow dipstick (LFD) for a rapid detection of respiratory diseases in cows. He presented the kit to the farmers in a convention followed by an on-field demonstration.
He joined the Biotigr team in 2016 as a postdoc researcher under the supervision of prof. Pierre Buffet. He spent 3 years in the Disease of Developing Unit (DDW) of GlaxoSmithKline (GSK) in Tres Cantos, Spain, acquiring a strong expertise in high-throughput screening (HTS). In collaboration with Julien Duez, he designed, developed and optimized an HTS based on microsphiltration technique to search for drugs than stiffen mature gametocytes of P.falciparum parasites, inducing their splenic retention and clearing from circulation.
He came back to Paris in 2019 to validate the drug leaders for malaria transmission blocking selected after the screening campaign.
For any further questions, please don’t hesitate to contact him.
Publications
– The human spleen in malaria: filter or shelter? Henry B, Roussell C, Carucci M, Brousse V, Ndour PA, Buffet P. Trends Parasitol. 2020 May. 36(5):435-446. Review.
– High throughput filtration to assess red blood cell deformability: a methodology to screen for malaria transmission-blocking drugs with wide applications in haematology. Duez J*, Carucci M*, Barbazán I, Corral M, Perez O, Presa J, Henry B, Roussel C, Ndour PA, Rosa N, Sanz L, Gamo FJ, Buffet PA. *Equal contribution. Nat. Protoc. 2018 May 24; 13(6):1362-1376.
– Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region. Gambini L, Rizzi L, Pedretti A, Taglialatela-Scafati O, Carucci M, Pancotti A, Galli C, Read M, Giurisato E, Romeo S, Russo I. PLoS One. 2016 Jan 4; 11(1):e0146627.