People

Pascal Amireault

Researcher, Spleen, Red cell Aging & Transfusion group group

INSERM
pascal.amireault@inserm.fr

Pierre Buffet

Professor, Spleen function in physiology and disease group

Université de Paris
pierre.buffet@inserm.fr

Aurélie Fricot

Engineer, Red cell clearance in Malaria, Spleen & Hemolytic anemia group

INSERM
aurelie.fricot@inserm.fr

Papa Alioune Ndour

Associate Professor, Red cell clearance in Malaria group

Université de Paris
alioune.ndour@inserm.fr

Sandy Peltier

PhD student, Spleen, Red cell Aging & Transfusion group group

INSERM
sandy.peltier@inserm.fr

Camille Roussel

MCU-PH, Spleen & Hemolytic anemia group

APHP-Université Paris Cité
camille.roussel@inserm.fr

Abdoulaye Sissoko

Post-Doc, Spleen function in physiology and disease group

U1134 / Institut Pasteur
abdoulaye.sissoko@inserm.fr

Valentin JOSTE

Post-Doc, Spleen function in physiology and disease group

U1134 / Institut Pasteur
valentinjoste@gmail.com

Mickael Marin

Engineer, Spleen, Red cell Aging & Transfusion group group


mickael.marin@inserm.fr

Alumni

Ben Othmene Yosra

Duverdier Clémence

Ben-Moumen Souheila

Cacan Zeynep

Leblanc Louise

Cissé Astan

Lavergne Alexis

Gauthier Raphaël

Perillaud Claire

Larreche Sebastien

Guery Romain

Tantaoui Ilhame

Taieb Aida

Siriez Jean-Yves

Chartrel Nathalie

Gay Frederick

Mouri Oussama

Ciceron Liliane

Danis Martin

Biligui Sylvestre

Diakite Seidina

Thellier Marc

Jaureguiberry Stephane

Duez Julien

Safeukui Innocent

Volle Geoffroy

Dépond Mallorie

Henry Benoît

Hadjou Youcef

Carret Valentine

Benletif Mounir

Diallo Aissatou Bailo

Chambrion Charlotte

Angella Lucia

Dumas Lucie

After I finished my DUT (Diplome Universitaire et Technologique) in Bioinformatics, I decided to stay in the biological field. That’s why I continued my carrier with a Bachelors degree in cellular biology and physiology and a Master degree in molecular and cellular biology, which I finish in 2020.  Shortly after, I accepted a one-year position as an engineer in the team of Prof. Pierre Buffet. Since November 2021, I have the honor to be a PhD student within his team. The title of my project is “Genesis and pitting of intra-erythrocytic vacuoles in hyposplenic subjects”.

Carucci Mario

In 2009, Mario got a master degree in biotechnology for human health from the Università di Siena in Italy. He studied the role of scaffold molecule KSR in cytotoxic activity of natural killer cells.

In 2015, he got a PhD in molecular pathogenesis, immunology and control of transmissible agents from the Università di Perugia, in Italy. He worked on the inhibition of Plasmespin V, an essential enzyme for protein export of P.falciparum parasites, a key factor in parasite’s virulence. He developed an innovative autologous expression system for large-scale production of P.falciparum proteins in the parasite itself, using the protein export system mediated by the Plasmepsin V.

After the PhD, he had a short six-months experience in applied research being responsible of a project called “Cow are you?” supported by Regione Umbria, in Italy. This project was focused on the design and production of a diagnostic kit based on lateral flow dipstick (LFD) for a rapid detection of respiratory diseases in cows. He presented the kit to the farmers in a convention followed by an on-field demonstration.

He joined the Biotigr team in 2016 as a postdoc researcher under the supervision of prof. Pierre Buffet. He spent 3 years in the Disease of Developing Unit (DDW) of GlaxoSmithKline (GSK) in Tres Cantos, Spain, acquiring a strong expertise in high-throughput screening (HTS). In collaboration with Julien Duez, he designed, developed and optimized an HTS based on microsphiltration technique to search for drugs than stiffen mature gametocytes of P.falciparum parasites, inducing their splenic retention and clearing from circulation.

He came back to Paris in 2019 to validate the drug leaders for malaria transmission blocking selected after the screening campaign.

For any further questions, please don’t hesitate to contact him.

 

Publications

 

– The human spleen in malaria: filter or shelter? Henry B, Roussell C, Carucci M, Brousse V, Ndour PA, Buffet P. Trends Parasitol. 2020 May. 36(5):435-446. Review.

– High throughput filtration to assess red blood cell deformability: a methodology to screen for malaria transmission-blocking drugs with wide applications in haematology. Duez J*, Carucci M*, Barbazán I, Corral M, Perez O, Presa J, Henry B, Roussel C, Ndour PA, Rosa N, Sanz L, Gamo FJ, Buffet PA. *Equal contribution. Nat. Protoc. 2018 May 24; 13(6):1362-1376.

 

– Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region. Gambini L, Rizzi L, Pedretti A, Taglialatela-Scafati O, Carucci M, Pancotti A, Galli C, Read M, Giurisato E, Romeo S, Russo I. PLoS One. 2016 Jan 4; 11(1):e0146627.