TEAM MEMBER

Abdoulaye Sissoko

Post-Doc, Spleen function in physiology and disease group

abdoulaye.sissoko@inserm.fr

Sissoko obtained his master degree in cell and molecular biology “specialized in parasitology” at Pierre and Marie Curie university, Paris. He had the chance to realize a six months internship on Saccharomyces cerevisiae as a model of cerebral disorder, the polymicrogyria which is related to human tubulin beta mutation. He focused on reproducing the F265L mutation on S. cerevisiae tubulin beta and undertook a functional study. Those results led to an original paper as co-author in Biology Open (2019).

Sissoko has then pursued with PhD thesis (2015-2018) in which he focused on elucidating artemisinins mechanism of action and targets in Plasmodium falciparum (Paris Descartes). He synthesized original fluorescent artemisinin-based probes which are the most similar to artemisinin derivatives, as compared to published artemisinin-probes so far. The obtained results led to three papers in 2020 as first author (one in ACS Infectious Diseases) and co-author (two in Communications Biology and BBA-Molecular Cell Research).

He joined the BioTiGr team in December 2019 as a postdoc fellow. He first worked for 1 year on validating malaria transmission blocking drugs in-vitro and in-vivo. Since February 2021, he is now focused on spleen function and markers in hyposlpenic, asplenic and splenectomized subjects.

 

Publications

1. A. Sissoko, A. Fricot-Monsinjon, C. Roussel, S. Manceau, L. Dumas, C. Capito, S. Allali, N. Yekkache, M. Dussiot, Y. Nguyen, A. Lefort Des Ylouses, B. Aussilhou, M. Tichit, D. Hardy, B. Maître, A. Eckly, M. De Montalembert, M. Cavazzana, L. Joseph, P. Buffet. Erythrocytic vacuoles that accumulate a fluorescent dye predict spleen size and function in sickle cell disease. American Journal of Hematology, 2022. DOI: 10.1002/ajh.26690

2. M. Carucci, J. Duez, J. Tarning, I. García-Barbazán, A. Fricot-Monsinjon, A. Sissoko, L. Dumas, P. Gamallo, B. Beher, P. Amireault, M. Dussiot, M. Dao, M. Hull, C. McNamara, C. Roussel, PA. Ndour, LM. Sanz, FJ. Gamo, P. Buffet. Safe drugs to block the transmission of malaria revealed by a spleen-mimetic screening approach. Nature communications, 2022 (accepté dans l’attente de dernières modifications)

3. Y. Qiang, A. Sissoko, Z L. Liu, T. Dong, F. Zheng, F. Kong, J M. Higgins, G E. Karniadakis, P A. Buffet*, Subra Suresh*, Ming Dao*. Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease. Proceedings of the National Academy of Sciences, 2022. https://doi.org/10.1073/pnas.2217607120

4. A. Sissoko, P. Vásquez-Ocmín, A. Maciuk, G. Neveu, D. Barbieri, R. Grougnet, M. Blaud, S. Michel, C. Lavazec, J. Clain, S. Houzé and R. Duval. A chemically-stable fluorescent mimic of artemether and arteether with conserved biological activity and specificity shows high mechanistic relevance to the clinical antimalarial drugs. ACS Infectious Diseases, 2020. DOI: 10.1021/acsinfecdis.9b00430

5. G. Bouyer, D. Barbieri, F. Dupuy, A. Marteau, A. Sissoko, M-E. N’Dri, G. Neveu, L. Bedault, D. Roman, G. Siciliano, P. Alano, R M. Martins, J-J. Lopez-Rubio, J. Clain, R. Duval, S. Egée and C. Lavazec. Activation of erythrocyte permeability enhances drug uptake by malaria sexual parasites. Communications Biology, 2020. DOI: 10.1038/s42003-020-01454-7

6. A. Laleve, C. Panozzo, I. Kühl, A. Bourand-Plantefol, J. Ostojic, A. Sissoko, D. Tribouillard-Tanvier, D. Cornu, A. Burg, B. Meunier, M. Blondel, J. Clain, N. Bonnefoy, R. Duval and G. Dujardin. Artemisinin and its derivatives early target mitochondrial cytochromes in yeast and human cells. BBA-Molecular Cell Research, 2020. DOI:10.1016/j.bbamcr.2020.118661

7. E. Denarier, C. Brousse, A. Sissoko, A. Andrieux and C. Boscheron. A neurodevelopmental TUBB2B β-tubulin mutation impairs Bim1 (yeast EB1)-dependent spindle positioning. Biology Open, 2019. DOI: 10.1242/bio.038620